Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220907 | 1.00 | MAP3K14 (0.43) | MAP3K14ADORA2APIK3CAMTORCLK1 | |
| SCHEMBL1614377 | 0.82 | ADORA2A (0.47) | MAP3K14ADORA2APIK3CAMTORCLK1 | |
| SCHEMBL3770639 | 0.79 | MAP3K14 (0.43) | MAP3K14ADORA2APIK3CAMTORTGFBR1 | |
| SCHEMBL21084989 | 0.79 | TGFBR1 (0.51) | TGFBR1 | |
| SCHEMBL1649588 | 0.77 | TGFBR1 (0.47) | MAP3K14ADORA2APIK3CAMTORCLK1 | |
| SCHEMBL3770636 | 0.77 | ADORA2A (0.43) | MAP3K14ADORA2APIK3CAMTORCLK1 | |
| SCHEMBL12850103 | 0.75 | ADORA2A (0.45) | MAP3K14ADORA2APIK3CAMTORCLK1 | |
| SCHEMBL15639434 | 0.75 | PIK3CA (0.45) | MAP3K14ADORA2APIK3CAMTORCLK1 | |
| SCHEMBL3845576 | 0.75 | ADORA2A (0.45) | MAP3K14ADORA2ACLK1TGFBR1GAA | |
| SCHEMBL26979552 | 0.75 | CLK1 (0.60) | ADORA2APIK3CAMTORCLK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1277754-B1 | IMIDAZOPYRIDINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-07-27 | — | — | EP | disclosed |
| US-6653320-B2 | Imidazopyridine derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-11-25 | — | — | US | disclosed |
| EP-1277754-A1 | IMIDAZOPYRIDINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-20020151549-A1 | Such as 3-(6-bromo-2-methylimidazo(1,2-a)pyridin-3-yl)-1H-pyrazol-1-yl 2-methyl-5-nitrophenyl sulfone; useful as phosphatidylinositol-3-kinase (PI3K) inhibitors and antitumor agents | ASTELLAS PHARMA INC. (JP) | 2002-10-17 | — | — | US | disclosed |
| US-6403588-B1 | PHOSPHATIDYLINOSITOL 3 KINASE (PI3K) INHIBITING ACTIVITY WHICH ARE USEFUL AS MEDICAMENTS, MORE PARTICULARLY AS ANTITUMOR AGENT | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151549-A1 | Such as 3-(6-bromo-2-methylimidazo(1,2-a)pyridin-3-yl)-1H-pyrazol-1-yl 2-methyl-5-nitrophenyl sulfone; useful as phosphatidylinositol-3-kinase (PI3K) inhibitors and antitumor agents | MTMR1, PIK3CA, PIK3CD | MAP3K14 105/4885ADORA2A 2338/4885PIK3CA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.