Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.49 |
| ▸ | HTR2A | P28223 | 11/20 | 0.49 |
| ▸ | HTR1A | P08908 | 10/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219285 | 0.93 | DRD2 (0.47) | DRD2HTR2AHTR1AHTR7SLC6A4 | |
| SCHEMBL6219855 | 0.88 | HTR2A (0.51) | DRD2HTR2AHTR1ASLC6A4HTR2C | |
| SCHEMBL6220416 | 0.81 | DRD2 (0.47) | DRD2HTR2AHTR1AHTR7SLC6A4 | |
| SCHEMBL6219541 | 0.80 | HTR2A (0.65) | DRD2HTR2AHTR1AHTR7HTR6 | |
| SCHEMBL6222349 | 0.78 | HTR2A (0.54) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL6221472 | 0.77 | DRD2 (0.44) | DRD2HTR2AHTR1AHTR7SLC6A4 | |
| SCHEMBL6218530 | 0.76 | HTR2A (0.51) | DRD2HTR2AHTR1AHTR7SLC6A4 | |
| SCHEMBL6219780 | 0.75 | PARP1 (0.42) | DRD2HTR2AHTR1AHTR7SLC6A4 | |
| SCHEMBL6220739 | 0.75 | HTR2A (0.70) | DRD2HTR2AHTR1AHTR7SLC6A4 | |
| SCHEMBL6219902 | 0.73 | PARP1 (0.44) | DRD2HTR2AHTR1AHTR7SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546143-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004026864-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-01 | — | — | WO | disclosed |