Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.49 |
| ▸ | ITGAL | P20701 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197641 | 0.86 | ITGB2 (0.61) | ITGB2ICAM1ITGALKDM4ENPC1 | |
| SCHEMBL6219767 | 0.84 | NPC1 (0.47) | ITGB2ICAM1ITGALKDM4ENPC1 | |
| SCHEMBL6219298 | 0.83 | ITGAL (0.54) | ITGB2ICAM1ITGALRAB9AENPP2 | |
| SCHEMBL6217580 | 0.80 | ITGB2 (0.50) | ITGB2ICAM1ITGALNPC1RAB9A | |
| SCHEMBL6196589 | 0.79 | ITGB2 (0.53) | ITGB2ICAM1ITGALKDM4ENPC1 | |
| SCHEMBL6196591 | 0.78 | ITGAL (0.79) | ITGB2ICAM1ITGALKDM4ENPC1 | |
| SCHEMBL6199078 | 0.77 | ITGB2 (0.52) | ITGB2ICAM1ITGALKDM4EENPP2 | |
| SCHEMBL6219332 | 0.76 | HTT (0.52) | ITGB2ICAM1ITGALKDM4ESMN1; SMN2 | |
| SCHEMBL6197647 | 0.75 | ITGAL (0.71) | ITGB2ICAM1ITGALKDM4ENPC1 | |
| SCHEMBL7611771 | 0.75 | ITGAL (0.71) | ITGB2ICAM1ITGALKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | claimed |