Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 4/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.50 |
| ▸ | ITGAL | P20701 | 4/20 | 0.50 |
| ▸ | CCNC | P24863 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197269 | 0.85 | ITGAL (0.63) | ITGB2ICAM1ITGALCCNCCDK8 | |
| SCHEMBL6219690 | 0.84 | ITGB2 (0.47) | ITGB2ICAM1ITGALCCNCCDK8 | |
| SCHEMBL6219298 | 0.82 | ITGAL (0.54) | ITGB2ICAM1ITGALCCNCCDK8 | |
| SCHEMBL6221012 | 0.80 | ITGB2 (0.49) | ITGB2ICAM1ITGALCCNCCDK8 | |
| SCHEMBL6218886 | 0.78 | ENPP2 (0.42) | ENPP2HTTLMNAPKMRAB9A | |
| SCHEMBL6198429 | 0.78 | ITGB2 (0.54) | ITGB2ICAM1ITGALCCNCCDK8 | |
| SCHEMBL6218188 | 0.78 | ITGAL (0.39) | ITGB2ICAM1ITGALENPP2HTT | |
| SCHEMBL6198436 | 0.78 | ITGAL (0.81) | ITGB2ICAM1ITGAL | |
| SCHEMBL6199078 | 0.75 | ITGB2 (0.52) | ITGB2ICAM1ITGALCCNCCDK8 | |
| SCHEMBL6311964 | 0.75 | ITGAL (0.77) | ITGB2ICAM1ITGALCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | claimed |