Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
| ▸ | PDE6A | P16499 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383320 | 1.00 | KCNH2 (0.41) | KCNH2GRM4KDM1AMAOAMAOB | |
| SCHEMBL4828194 | 0.89 | GRM4 (0.45) | KCNH2GRM4KDM1AMAOAMAOB | |
| SCHEMBL1384788 | 0.87 | KCNH2 (0.39) | KCNH2KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL1382638 | 0.86 | GRM4 (0.38) | KCNH2GRM4MAPK1CYP3A4USP2 | |
| SCHEMBL6226746 | 0.86 | GRM4 (0.38) | KCNH2GRM4MAPK1CYP3A4USP2 | |
| SCHEMBL1929839 | 0.85 | KDR (0.42) | KCNH2GRM4KDM1AMAOAMAOB | |
| SCHEMBL1387010 | 0.80 | IRAK4 (0.38) | GRM4MAPK1PDE5ACYP3A4USP2 | |
| SCHEMBL4832226 | 0.80 | IRAK4 (0.38) | GRM4MAPK1PDE5ACYP3A4USP2 | |
| SCHEMBL1382994 | 0.78 | GRM4 (0.40) | KCNH2GRM4LMNA | |
| SCHEMBL4830087 | 0.74 | GRM4 (0.47) | GRM4KAT2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254138-B1 | PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE | NOVARTIS AG (CH) | 2005-05-11 | — | — | EP | claimed |