Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.33 |
| ▸ | MERTK | Q12866 | 2/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | WHR1 | P49842 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382638 | 1.00 | GRM4 (0.38) | GRM4KDM4EHSD17B10SRCCYP11B1 | |
| SCHEMBL4830087 | 0.88 | GRM4 (0.47) | GRM4KDM4ECYP11B1CYP11B2FLT3 | |
| SCHEMBL1385914 | 0.86 | CHRM1 (0.30) | CHRM1 | |
| SCHEMBL6221506 | 0.86 | KCNH2 (0.41) | GRM4CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL1383320 | 0.86 | KCNH2 (0.41) | GRM4CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL4679265 | 0.84 | KDM4E (0.40) | GRM4KDM4EHSD17B10WHR1 | |
| SCHEMBL1931665 | 0.84 | KDM4E (0.40) | GRM4KDM4EHSD17B10WHR1 | |
| SCHEMBL1382994 | 0.79 | GRM4 (0.40) | GRM4KDM4EHSD17B10IRAK4CHRM1 | |
| SCHEMBL4825401 | 0.79 | GRM4 (0.39) | GRM4KDM4EHSD17B10TYRO3MERTK | |
| SCHEMBL1383698 | 0.79 | GRM4 (0.39) | GRM4KDM4EHSD17B10TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254138-B1 | PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE | NOVARTIS AG (CH) | 2005-05-11 | — | — | EP | claimed |