SCHEMBL6222767

SCHEMBL6222767

N#C/C=C/c1cccc(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.56
CYP1A2 P05177 2/20 0.52
CYP2C9 P11712 1/20 0.52
FBP1 P09467 1/20 0.49
CHAT P28329 1/20 0.49
CHRM5 P08912 1/20 0.48
RELA Q04206 1/20 0.47
GAA P10253 1/20 0.45
MAPT P10636 1/20 0.45
MAOB P27338 5/20 0.45
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 1/20 0.43
POLB P06746 1/20 0.43
PKM P14618 1/20 0.43
KMT2A Q03164 1/20 0.43
MAOA P21397 3/20 0.41
AKR1C3 P42330 1/20 0.41
XPO1 O14980 1/20 0.41
CYP1A1 P04798 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6222770 1.00 ENPP2 (0.56) ENPP2CYP1A2CYP2C9FBP1CHAT
SCHEMBL27698353 0.80 ENPP2 (0.49) ENPP2CYP1A2CYP2C9MAOBKDM4E
SCHEMBL699364 0.80 CHAT (0.67) CYP1A2CYP2C9FBP1CHATCHRM5
SCHEMBL699365 0.80 CHAT (0.67) CYP1A2CYP2C9FBP1CHATCHRM5
SCHEMBL2349002 0.80 CYP1A2 (0.56) CYP1A2CYP2C9FBP1CHATCHRM5
SCHEMBL2349000 0.80 CYP1A2 (0.56) CYP1A2CYP2C9FBP1CHATCHRM5
SCHEMBL7216919 0.79 CHRM5 (0.52) CYP1A2CYP2C9FBP1CHATCHRM5
SCHEMBL27878915 0.79 XPO1 (0.42) ENPP2CYP1A2CYP2C9RELAMAOB
SCHEMBL7429376 0.79 AHR (0.48) ENPP2GAAMAPTKDM4EALDH1A1
SCHEMBL3606954 0.79 AHR (0.48) ENPP2GAAMAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3553097-B1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORP (JP) 2022-05-04 EP disclosed
US-11225540-B2 Copolymer and optical film using same TOSOH CORPORATION (JP) 2022-01-18 US disclosed
CN-110248971-B Copolymer and optical film using the same 东曹株式会社 2021-11-02 CN disclosed
US-20200095358-A1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORPORATION (JP) 2020-03-26 US disclosed
EP-3553097-A1 COPOLYMER AND OPTICAL FILM USING SAME Tosoh Corporation (JP) 2019-10-16 EP disclosed
CN-110248971-A Copolymer and the optical film for using the copolymer 东曹株式会社 2019-09-17 CN disclosed
US-8962596-B2 5,7-substituted-imidazo[1,2-C]pyrimidines as inhibitors of JAK kinases ARRAY BIOPHARMA INC. (US) 2015-02-24 US disclosed
US-20130131039-A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES ARRAY BIOPHARMA INC. (US) 2013-05-23 US disclosed
CN-100558698-C Calcium Receptor Active Compounds NPS PHARMA INC (US) 2009-11-11 CN disclosed
CN-1312116-C Calcium Receptor Active Compounds NPS PHARMA INC (US) 2007-04-25 CN disclosed
CN-1534016-A Calcium Receptor Active Compounds NPSҩ�����޹�˾ 2004-10-06 CN disclosed
CN-1147459-C Calcium Receptor Active Compounds NPSҩ�����޹�˾ 2004-04-28 CN disclosed
EP-1275635-A1 Calcium receptor-active compounds NPS PHARMACEUTICALS, INC. (US) 2003-01-15 EP disclosed
EP-1203761-A2 Calcium receptor-active compounds NPS PHARMACEUTICALS, INC. (US) 2002-05-08 EP disclosed
US-6211244-B1 AROMATIC AMINES FOR COMPLEXING CALCIUM NPS PHARMACEUTICALS, INC. 2001-04-03 US disclosed
WO-1996012697-A9 CALCIUM RECEPTOR-ACTIVE COMPOUNDS NPS PHARMA INC (US) 2000-08-24 WO disclosed
CN-1220658-A Calcium Receptor Active Compounds NPS PHARMA INC (US) 1999-06-23 CN disclosed
EP-0787122-A2 CALCIUM RECEPTOR-ACTIVE COMPOUNDS NPS PHARMACEUTICALS, INC. (US) 1997-08-06 EP disclosed
WO-1996012697-A2 CALCIUM RECEPTOR-ACTIVE COMPOUNDS NPS PHARMACEUTICALS, INC. (US) 1996-05-02 WO disclosed
US-4012377-A ANTIMICROBIAL, PARASITICIDES GLAXO LABORATORIES LIMITED (EN) 1977-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130131039-A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES JAK1, JAK3, JAK2 ENPP2 2025/4885CYP1A2 1615/4885CYP2C9 831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.