Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ASPH | Q12797 | 3/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150923 | 0.89 | KDM5B (0.43) | LOXLOXL2KMT2AKDM4EASPH | |
| SCHEMBL6223073 | 0.75 | KCNB1 (0.41) | KMT2AKDM4EASPHKDM8MEN1 | |
| SCHEMBL3146401 | 0.74 | KDM5B (0.62) | LOXLOXL2KMT2AKDM4EASPH | |
| SCHEMBL6951705 | 0.73 | LOX (0.51) | LOXLOXL2KMT2AKDM4EFFAR1 | |
| SCHEMBL14734428 | 0.72 | KDM4E (0.54) | KMT2AKDM4EASPHKDM8MEN1 | |
| SCHEMBL19049441 | 0.71 | MTNR1A (0.61) | LOXLOXL2KDM4EMAPTALDH1A1 | |
| SCHEMBL29886245 | 0.69 | FFAR1 (0.67) | LOXLOXL2FFAR1SLC13A5 | |
| SCHEMBL3724453 | 0.69 | FFAR1 (0.67) | LOXLOXL2FFAR1SLC13A5 | |
| SCHEMBL21591538 | 0.69 | GSK3A (0.50) | LOXLOXL2KDM4EFFAR1GSK3B | |
| SCHEMBL19002284 | 0.69 | MTNR1A (0.53) | LOXLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |