Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27901523 | 0.88 | EGLN1 (0.45) | EGLN1ADORA2ABCHEACHE | |
| SCHEMBL623390 | 0.82 | ADORA2A (0.52) | EGLN1ADORA2AIP6K1LMNAHTT | |
| SCHEMBL626904 | 0.82 | EGLN1 (0.66) | EGLN1ADORA2A | |
| SCHEMBL622935 | 0.79 | EGLN1 (0.73) | EGLN1 | |
| SCHEMBL14992287 | 0.79 | EGLN1 (0.48) | EGLN1ADORA2AHTT | |
| SCHEMBL627008 | 0.77 | HTT (0.50) | EGLN1ADORA2ALMNAHTT | |
| SCHEMBL14992371 | 0.77 | EGLN1 (0.49) | EGLN1HTT | |
| SCHEMBL27901534 | 0.76 | ADORA2A (0.43) | EGLN1ADORA2ALMNAHTT | |
| SCHEMBL14992102 | 0.76 | EGLN1 (0.40) | EGLN1ADORA2ALMNAHTT | |
| SCHEMBL28802325 | 0.76 | ADORA2A (0.47) | EGLN1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603502-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-06-19 | — | — | EP | disclosed |
| CN-103068821-A | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV | 2013-04-24 | — | — | CN | disclosed |
| WO-2012021830-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-16 | — | — | WO | disclosed |