Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627008 | 0.94 | HTT (0.50) | ADORA2AEGLN1GLAHSD17B10GAA | |
| SCHEMBL27919330 | 0.86 | ADORA2A (0.52) | ADORA2AEGLN1GLATSHRHSD17B10 | |
| SCHEMBL627779 | 0.83 | EGLN1 (0.49) | ADORA2AEGLN1GLATSHRHSD17B10 | |
| SCHEMBL28802325 | 0.82 | ADORA2A (0.47) | ADORA2AEGLN1 | |
| SCHEMBL622332 | 0.82 | EGLN1 (0.45) | ADORA2AEGLN1IP6K1LMNAHTT | |
| SCHEMBL27901521 | 0.81 | EGLN1 (0.67) | ADORA2AEGLN1 | |
| SCHEMBL627423 | 0.81 | HTT (0.50) | ADORA2AEGLN1GLAHSD17B10GAA | |
| SCHEMBL627435 | 0.81 | EGLN1 (0.50) | ADORA2AEGLN1GLATSHRHSD17B10 | |
| SCHEMBL627589 | 0.80 | EGLN1 (0.47) | ADORA2AEGLN1GLATSHRHSD17B10 | |
| SCHEMBL626312 | 0.79 | ADORA2A (0.54) | ADORA2AEGLN1GLATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603502-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-06-19 | — | — | EP | disclosed |
| CN-103068821-A | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV | 2013-04-24 | — | — | CN | disclosed |
| WO-2012021830-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-16 | — | — | WO | disclosed |