Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.58 |
| ▸ | MTOR | P42345 | 10/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | PRKACG | P22612 | 1/20 | 0.55 |
| ▸ | PRKACB | P22694 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.51 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624965 | 0.80 | MTOR (0.61) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL622969 | 0.77 | PIK3CA (0.55) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL624292 | 0.75 | PIK3CA (0.56) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL10092302 | 0.74 | PIK3CA (0.78) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL12464274 | 0.74 | PIK3CA (0.64) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL12464157 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL28799921 | 0.72 | PIK3CA (0.77) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL959704 | 0.72 | PIK3CA (0.80) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL258501 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL29395747 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020227-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |