Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 8/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223756 | 1.00 | GRM4 (0.43) | GRM4GBA1PDE4BPDE7ALMNA | |
| SCHEMBL1383329 | 1.00 | GRM4 (0.43) | GRM4GBA1PDE4BPDE7ALMNA | |
| SCHEMBL1382994 | 0.88 | GRM4 (0.40) | GRM4GBA1LMNAIRAK4 | |
| SCHEMBL1386115 | 0.86 | GBA1 (0.53) | GBA1PDE4BPDE7ALMNAPOLB | |
| SCHEMBL6223769 | 0.86 | GBA1 (0.53) | GBA1PDE4BPDE7ALMNAPOLB | |
| SCHEMBL6223107 | 0.86 | GBA1 (0.53) | GBA1PDE4BPDE7ALMNAPOLB | |
| SCHEMBL6223355 | 0.85 | ALDH1A1 (0.41) | GBA1PDE4BPDE7ALMNAPOLB | |
| SCHEMBL1383369 | 0.85 | ALDH1A1 (0.41) | GBA1PDE4BPDE7ALMNAPOLB | |
| SCHEMBL6219896 | 0.85 | ALDH1A1 (0.41) | GBA1PDE4BPDE7ALMNAPOLB | |
| SCHEMBL4825401 | 0.83 | GRM4 (0.39) | GRM4CYP1A2CYP2D6TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254138-B1 | PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE | NOVARTIS AG (CH) | 2005-05-11 | — | — | EP | claimed |
| EP-1603566-B1 | USE OF ISOQUINOLINE DERIVATIVES FOR TREATING CANCER AND MAP KINASE RELATED DISEASES | NOVARTIS AG (CH) | 2009-01-21 | — | — | EP | disclosed |