Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 12/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.54 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6223706 | 0.95 | CDC7 (0.52) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL6224007 | 0.90 | CDC7 (0.71) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL6747837 | 0.84 | MAPKAPK2 (0.53) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| Trifluoroacetic Acid SCHEMBL6224214 | 0.82 | MAPKAPK2 (0.54) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| Trifluoroacetic Acid SCHEMBL6224319 | 0.78 | MAPKAPK2 (0.58) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL6223709 | 0.77 | PLK4 (0.35) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL6224323 | 0.77 | MAPKAPK2 (0.56) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL4513746 | 0.73 | CDC7 (1.00) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL4513750 | 0.73 | CDC7 (1.00) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 | |
| SCHEMBL4518010 | 0.73 | CDC7 (0.75) | CDC7MAPKAPK2CDK1MAPKAPK3MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572693-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040209897-A1 | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds | PHARMACIA CORPORATION | 2004-10-21 | — | — | US | disclosed |
| WO-2004058762-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209897-A1 | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds | MAPKAPK2, MAP3K2, MKNK2 | CDC7 277/4885MAPKAPK2 1/4885CDK1 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.