Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 14/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.53 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224323 | 0.90 | MAPKAPK2 (0.56) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| Trifluoroacetic Acid SCHEMBL6224214 | 0.87 | MAPKAPK2 (0.54) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| Trifluoroacetic Acid SCHEMBL6223706 | 0.87 | CDC7 (0.52) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| SCHEMBL6223993 | 0.84 | CDC7 (0.57) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| Trifluoroacetic Acid SCHEMBL6224319 | 0.84 | MAPKAPK2 (0.58) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| SCHEMBL6224007 | 0.77 | CDC7 (0.71) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| Trifluoroacetic Acid SCHEMBL6227476 | 0.73 | MAPKAPK2 (0.84) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| SCHEMBL6223709 | 0.73 | PLK4 (0.35) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| SCHEMBL15508853 | 0.70 | MAPKAPK2 (1.00) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 | |
| SCHEMBL6225761 | 0.70 | MAPKAPK2 (0.59) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040209897-A1 | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds | PHARMACIA CORPORATION | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209897-A1 | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds | MAPKAPK2, MAP3K2, MKNK2 | MAPKAPK2 1/4885CDK1 112/4885MAPKAPK3 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.