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SCHEMBL6224284

SCHEMBL6224284

CCN(CCO)CC(=O)Nc1cccc(-c2nc(-c3ccccc3)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ LHCGR P22888 9/20 0.50
▸ FSHR P23945 2/20 0.49
▸ TSHR P16473 2/20 0.47
▸ BRAF P15056 7/20 0.41
▸ KMT2A Q03164 2/20 0.37
▸ POLB P06746 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5026134 0.90 BRAF (0.51) BRAFMAPT
SCHEMBL5028901 0.87 LHCGR (0.54) LHCGRFSHRTSHRBRAFKMT2A
SCHEMBL5028895 0.85 LHCGR (0.54) LHCGRFSHRTSHRBRAFMAPT
SCHEMBL6221403 0.83 LHCGR (0.52) LHCGRFSHRTSHRBRAFKMT2A
SCHEMBL4426367 0.83 LHCGR (0.55) LHCGRFSHRTSHRBRAFKMT2A
SCHEMBL5026184 0.82 LHCGR (0.48) LHCGRFSHRTSHRBRAFKMT2A
SCHEMBL6222882 0.82 LHCGR (0.48) LHCGRFSHRTSHRBRAFKMT2A
SCHEMBL5026105 0.82 LHCGR (0.65) LHCGRFSHRTSHR
SCHEMBL6221999 0.82 LHCGR (0.51) LHCGRFSHRTSHRBRAFKMT2A
SCHEMBL5026187 0.82 LHCGR (0.52) LHCGRFSHRTSHRBRAFKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1427734-B1 GLYCINE-SUBSTITUTED THIENO[2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY AKZO NOBEL NV (NL) 2005-11-09 — — EP claimed