Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.58 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.58 |
| ▸ | PLG | P00747 | 1/20 | 0.57 |
| ▸ | PROC | P04070 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224911 | 0.92 | F10 (0.52) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL6222788 | 0.90 | F10 (0.60) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL6226434 | 0.89 | F10 (0.61) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL6224834 | 0.89 | F10 (0.63) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL6223414 | 0.88 | F10 (0.61) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL6224269 | 0.87 | F10 (0.49) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL6221817 | 0.87 | F10 (0.61) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL6225168 | 0.87 | F10 (0.61) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7099736 | 0.86 | F10 (0.62) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL6223215 | 0.86 | PRSS1 (0.51) | F10PRSS1PRSS2PRSS3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311476-B1 | AZA-AMINO ACID DERIVATIVES (FACTOR X A?-INHIBITORS 15) | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | claimed |
| US-6849626-B2 | Aza-amino acid derivatives (factor Xa inhibitors 15) | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | claimed |
| US-20040034072-A1 | Aza-amino acid derivatives (factor Xa inhibitors 15) | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | claimed |
| EP-1311476-A1 | AZA-AMINO ACID DERIVATIVES (FACTOR X A?-INHIBITORS 15) | MERCK PATENT GmbH (DE) | 2003-05-21 | — | — | EP | claimed |
| WO-2002016315-A1 | AZA-AMINO ACID DERIVATIVES (FACTOR XA-INHIBITORS 15) | MERCK PATENT GMBH (DE) | 2002-02-28 | — | — | WO | claimed |
| EP-1311476-B1 | AZA-AMINO ACID DERIVATIVES (FACTOR X A?-INHIBITORS 15) | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | disclosed |
| US-6849626-B2 | Aza-amino acid derivatives (factor Xa inhibitors 15) | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |
| US-20040034072-A1 | Aza-amino acid derivatives (factor Xa inhibitors 15) | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | disclosed |
| EP-1311476-A1 | AZA-AMINO ACID DERIVATIVES (FACTOR X A?-INHIBITORS 15) | MERCK PATENT GmbH (DE) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002016315-A1 | AZA-AMINO ACID DERIVATIVES (FACTOR XA-INHIBITORS 15) | MERCK PATENT GMBH (DE) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034072-A1 | Aza-amino acid derivatives (factor Xa inhibitors 15) | AZI2, F11, SERPINE1 | F10 32/4885PRSS1 219/4885PRSS2 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.