Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 14/20 | 0.47 |
| ▸ | CNR1 | P21554 | 13/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559134 | 0.85 | CNR2 (0.59) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL6223184 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL5559142 | 0.83 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL6220300 | 0.82 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6223554 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6223648 | 0.80 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6221453 | 0.80 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL6222988 | 0.76 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5558009 | 0.72 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL5559131 | 0.70 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330455-B1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2005-08-03 | — | — | EP | claimed |
| EP-1330455-A1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | Elbion AG (DE) | 2003-07-30 | — | — | EP | claimed |
| WO-2002034747-A1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2002-05-02 | — | — | WO | claimed |
| EP-1330455-B1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2005-08-03 | — | — | EP | disclosed |