Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 3/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220300 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5552779 | 0.84 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6223184 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5557051 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6221453 | 0.82 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6223368 | 0.81 | HTR3A (0.40) | ELANE | |
| SCHEMBL6224705 | 0.81 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6223648 | 0.80 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL6223244 | 0.80 | EPHX1 (0.40) | MAPTKMT2ANPSR1 | |
| SCHEMBL6223291 | 0.80 | HTR3A (0.39) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330455-B1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2005-08-03 | — | — | EP | claimed |
| EP-1330455-A1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | Elbion AG (DE) | 2003-07-30 | — | — | EP | claimed |
| WO-2002034747-A1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2002-05-02 | — | — | WO | claimed |
| EP-1330455-B1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2005-08-03 | — | — | EP | disclosed |