Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.85 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221504 | 0.92 | MAPK14 (1.00) | MAPK14 | |
| Hydrochloric Acid SCHEMBL6221481 | 0.87 | MAPK14 (0.70) | MAPK14RAF1BRAF | |
| SCHEMBL6224025 | 0.87 | MAPK14 (0.81) | MAPK14RAF1BRAF | |
| SCHEMBL6970752 | 0.85 | MAPK14 (0.66) | MAPK14RAF1BRAF | |
| SCHEMBL6976106 | 0.84 | MAPK14 (0.60) | MAPK14RAF1BRAF | |
| SCHEMBL6980605 | 0.82 | MAPK14 (0.59) | MAPK14RAF1BRAF | |
| SCHEMBL6220971 | 0.82 | MAPK14 (1.00) | MAPK14RAF1BRAF | |
| SCHEMBL6223233 | 0.82 | MAPK14 (0.81) | MAPK14RAF1BRAF | |
| SCHEMBL6221718 | 0.81 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL6221940 | 0.81 | MAPK14 (1.00) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846827-B1 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-01-25 | — | — | US | disclosed |
| EP-1226126-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-01-05 | — | — | EP | disclosed |