SCHEMBL6224820

SCHEMBL6224820

CO/C=C(/C(=O)O)c1ccccc1CON=C(C1CC1)[C@@H]1C[C@H]1c1cccc(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 1/20 0.38
GPR88 Q9GZN0 1/20 0.35
LMNA P02545 2/20 0.35
TRPM5 Q9NZQ8 2/20 0.34
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
PTGS2 P35354 1/20 0.33
MDM2 Q00987 3/20 0.33
TP53 P04637 2/20 0.33
NR1H4 Q96RI1 1/20 0.32
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6561782 0.76 MAPK1 (0.37) SLC9A1TRPM5MEN1ALDH1A1MAPT
SCHEMBL6561780 0.76 MAPK1 (0.37) SLC9A1TRPM5MEN1ALDH1A1MAPT
SCHEMBL6561354 0.76 MAPK1 (0.37) SLC9A1TRPM5MEN1ALDH1A1KMT2A
SCHEMBL6561351 0.76 MAPK1 (0.37) SLC9A1TRPM5MEN1ALDH1A1KMT2A
SCHEMBL8077647 0.75 HIF1A (0.36) SLC9A1GPR88
SCHEMBL6561459 0.74 MAPK1 (0.34) SLC9A1GPR88TRPM5MEN1KMT2A
SCHEMBL6561462 0.74 MAPK1 (0.34) SLC9A1GPR88TRPM5MEN1KMT2A
SCHEMBL6561882 0.73 MAPK1 (0.35) GPR88TRPM5MEN1KMT2APTGS2
SCHEMBL6561885 0.73 MAPK1 (0.35) GPR88TRPM5MEN1KMT2APTGS2
SCHEMBL6561217 0.73 MAPK1 (0.35) TRPM5MEN1KMT2APTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1026151-B1 Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides DOW AGROSCIENCES LLC (US) 2005-03-16 EP disclosed
EP-1026151-A1 Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides ROHM AND HAAS COMPANY (US) 2000-08-09 EP disclosed
US-6063956-A APPLYING FUNGICIDE OR INSECTICIDE TO THE LOCUS WHERE CONTROL IS DESIRED ROHM AND HAAS COMPANY (US) 2000-05-16 US disclosed