Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14595530 | 0.85 | CBFB (0.51) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL4539127 | 0.81 | P2RX7 (0.54) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL21753409 | 0.77 | CBFB (0.44) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL21753230 | 0.77 | KDM4E (0.47) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL21769973 | 0.77 | CBFB (0.53) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL5803772 | 0.77 | ERN1 (0.48) | CBFBCYP1A2KDM4EPOLBCYP2D6 | |
| SCHEMBL19794413 | 0.77 | PDK2 (0.47) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL27357757 | 0.75 | DCLRE1A (0.43) | CYP1A2KDM4ELMNA | |
| SCHEMBL30462045 | 0.72 | KDM4E (0.50) | CBFBDHODHCYP1A2CCR1CCR5 | |
| SCHEMBL533591 | 0.72 | KDM4E (0.50) | CBFBDHODHCYP1A2CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534676-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | Oxford GlycoSciences (UK) Limited (GB) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007453-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-01-22 | — | — | WO | disclosed |