Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223627 | 0.85 | HRH3 (0.56) | HRH3OPRM1OPRD1HRH1OPRK1 | |
| SCHEMBL6225071 | 0.85 | HRH3 (0.42) | HRH3OPRM1OPRD1HPGDSHTR2B | |
| SCHEMBL5194058 | 0.81 | HRH3 (0.41) | HRH3OPRM1OPRD1 | |
| SCHEMBL3100067 | 0.79 | HRH3 (0.48) | HRH3GPR119ABCB1 | |
| SCHEMBL5713478 | 0.76 | HRH3 (0.45) | HRH3OPRM1OPRD1ABCB1OPRK1 | |
| SCHEMBL5169161 | 0.76 | PRMT5 (0.36) | HRH3GPR119HTR2A | |
| SCHEMBL13180002 | 0.75 | HRH3 (0.47) | HRH3OPRM1OPRD1GPR119HRH1 | |
| SCHEMBL3077365 | 0.74 | HRH3 (0.73) | HRH3HRH1 | |
| SCHEMBL6228806 | 0.74 | GRIN1 (0.40) | — | |
| SCHEMBL6226193 | 0.72 | HRH3 (0.41) | HRH3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572215-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056369-A1 | BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |