Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223629 | 0.86 | HRH3 (0.54) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL6225069 | 0.85 | HRH3 (0.44) | HRH3OPRM1OPRD1OPRK1HTR2B | |
| SCHEMBL5194064 | 0.82 | HRH3 (0.40) | HRH3OPRM1OPRD1 | |
| SCHEMBL5169168 | 0.78 | PRMT5 (0.37) | HRH3SLC18A2 | |
| SCHEMBL5713479 | 0.77 | HRH3 (0.46) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL6228809 | 0.76 | GRIN1 (0.40) | HRH3MEN1KMT2ASLC18A2KDM4E | |
| SCHEMBL6226195 | 0.74 | HRH3 (0.39) | HRH3MEN1KMT2ASMN1; SMN2HTR1A | |
| SCHEMBL3100067 | 0.74 | HRH3 (0.48) | HRH3KMT2AABCB1 | |
| SCHEMBL6225384 | 0.73 | SMN1; SMN2 (0.40) | HRH3MEN1KMT2ASMN1; SMN2SLC18A2 | |
| SCHEMBL5170957 | 0.73 | CHRNB2 (0.38) | HRH3SLC18A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572215-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056369-A1 | BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |