SCHEMBL6225320

SCHEMBL6225320

CCOC(=O)/C=C(C)/C=C/[C@@H]1C[C@]1(C)c1ccc2c(c1)C(C)(C)CCN2C(=O)OC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RXRA P19793 12/20 0.49
RXRG P48443 10/20 0.49
RXRB P28702 8/20 0.49
RARB P10826 8/20 0.49
RARA P10276 6/20 0.49
RARG P13631 4/20 0.49
PPARG P37231 1/20 0.49
KDM1A O60341 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6225322 1.00 RXRA (0.49) RXRARXRGRXRBRARBRARA
SCHEMBL7030854 1.00 RXRA (0.49) RXRARXRGRXRBRARBRARA
SCHEMBL6222353 0.90 RXRA (0.54) RXRARXRGRXRBRARBRARA
SCHEMBL6222487 0.90 RXRA (0.54) RXRARXRGRXRBRARBRARA
SCHEMBL6223471 0.89 RXRA (0.63) RXRARXRGRXRBRARBRARA
SCHEMBL6225268 0.83 RXRA (0.54) RXRARXRGRXRBRARBRARA
SCHEMBL6225273 0.83 RXRA (0.54) RXRARXRGRXRBRARBRARA
SCHEMBL8334596 0.81 RXRA (0.74) RXRARXRGRXRBRARBRARA
SCHEMBL21017664 0.81 RXRA (0.74) RXRARXRGRXRBRARBRARA
SCHEMBL8340075 0.81 RXRA (0.74) RXRARXRGRXRBRARBRARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1117648-B1 TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS ALLERGAN INC (US) 2003-08-06 EP claimed
EP-1117648-A1 TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS Allergan Sales, Inc. (US) 2001-07-25 EP claimed
WO-2000020397-A1 TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS ALLERGAN SALES, INC. (US) 2000-04-13 WO claimed
US-6048873-A SKIN DISORDERS ALLERGAN SALES, INC. (US) 2000-04-11 US claimed
EP-1354878-B1 Tetrahydroquinoline derivatives having selective activity for retinoid x receptors ALLERGAN INC (US) 2005-11-23 EP disclosed
EP-1354878-A2 Tetrahydroquinoline derivatives having selective activity for retinoid x receptors Allergan, Inc. (US) 2003-10-22 EP disclosed
EP-1117648-B1 TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS ALLERGAN INC (US) 2003-08-06 EP disclosed
EP-1117648-A1 TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS Allergan Sales, Inc. (US) 2001-07-25 EP disclosed
WO-2000020397-A1 TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS ALLERGAN SALES, INC. (US) 2000-04-13 WO disclosed
US-6048873-A SKIN DISORDERS ALLERGAN SALES, INC. (US) 2000-04-11 US disclosed