Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mosapride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | HTR2B | P41595 | 1/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.98 |
| ▸ | DRD4 | P21917 | 12/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mosapride SCHEMBL6227991 | 1.00 | DRD3 (0.98) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL6228981 | 0.99 | DRD3 (1.00) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL16417 | 0.99 | DRD3 (1.00) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL29400580 | 0.99 | DRD3 (1.00) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL2369236 | 0.98 | DRD3 (0.98) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL5150929 | 0.98 | DRD3 (0.97) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL6229365 | 0.95 | DRD3 (0.91) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL7364946 | 0.93 | KCNH2 (0.88) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8004478 | 0.92 | DRD3 (0.86) | DRD3MEN1LMNACYP1A2CYP3A4 | |
| Mosapride SCHEMBL258620 | 0.91 | DRD3 (0.85) | DRD3MEN1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110721151-B | Simethicone compound liquid composition and preparation method and application thereof | 远大生命科学(武汉)有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-114671826-A | Mosapride organic acid crystal | 鲁南制药集团股份有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-114591260-A | Mosapride organic acid salt | 鲁南制药集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-107456444-B | Mosapride sustained-release dry suspension and preparation method thereof | 南京百思福医药科技有限公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-112739680-A | DP antagonists | 小野药品工业株式会社 | 2021-04-30 | — | — | CN | disclosed |
| CN-111505154-A | Detection method for mosapride citrate and five key impurities in preparation thereof | 南京百思福医药科技有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-110721151-A | Simethicone compound liquid composition and preparation method and application thereof | 武汉大安制药有限公司 | 2020-01-24 | — | — | CN | disclosed |
| CN-107456444-A | Mosapride sustained-release dry suspension and preparation method thereof | 南京工业大学 | 2017-12-12 | — | — | CN | disclosed |
| EP-1515958-A2 | PROCESS FOR THE SYNTHESIS OF MOSAPRIDE | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003106440-A2 | PROCESS FOR THE SYNTHESIS OF A BENZAMIDE DERIVATIVE | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-12-24 | — | — | WO | disclosed |