Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 8/20 | 0.55 |
| ▸ | FSHR | P23945 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 10/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221309 | 0.91 | LHCGR (0.52) | LHCGRFSHRTSHRBRAFPDE4A | |
| SCHEMBL5028890 | 0.90 | BRAF (0.58) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6220667 | 0.88 | LHCGR (0.53) | LHCGRFSHRTSHRBRAFMEN1 | |
| SCHEMBL6221420 | 0.87 | LHCGR (0.69) | LHCGRFSHRTSHR | |
| SCHEMBL5026188 | 0.86 | LHCGR (0.51) | LHCGRFSHRTSHRBRAFPDE4A | |
| SCHEMBL6227679 | 0.85 | LHCGR (0.49) | LHCGRFSHRTSHRBRAFMEN1 | |
| SCHEMBL6221999 | 0.84 | LHCGR (0.51) | LHCGRFSHRTSHRBRAFPDE4A | |
| SCHEMBL6224121 | 0.84 | LHCGR (0.51) | LHCGRFSHRTSHRBRAFMEN1 | |
| SCHEMBL5030898 | 0.81 | BRAF (0.53) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5030974 | 0.77 | LHCGR (0.53) | LHCGRFSHRTSHRBRAFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427734-B1 | GLYCINE-SUBSTITUTED THIENO[2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | AKZO NOBEL NV (NL) | 2005-11-09 | — | — | EP | claimed |