Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157878 | 0.86 | ADORA1 (0.52) | ADORA1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL8694949 | 0.82 | KDM4E (0.47) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8693742 | 0.82 | CYP1A2 (0.45) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8193560 | 0.81 | KDM4E (0.77) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8696874 | 0.78 | ALDH1A1 (0.54) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6221477 | 0.78 | KDM4E (0.49) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6222281 | 0.77 | KDM4E (0.47) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27453761 | 0.77 | KDM4E (0.47) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8192913 | 0.76 | ALDH1A1 (0.57) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6221158 | 0.76 | ADORA1 (0.49) | ADORA1KDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225173-B1 | NAPHTHYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2005-09-28 | — | — | EP | disclosed |
| US-6740662-B1 | HAVING 2-OXO-1,2-DIHYDRO- FUNCTIONALITY; PHOSPHODIESTERASE INHIBITORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-05-25 | — | — | US | disclosed |
| CN-1148369-C | 1,8-naphthyridine derivatives | ֮����ҩ��ʽ���� | 2004-05-05 | — | — | CN | disclosed |
| CN-1382141-A | 1,8-naphthyridine derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 2002-11-27 | — | — | CN | disclosed |
| EP-1225173-A1 | NAPHTHYRIDINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-07-24 | — | — | EP | disclosed |