Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 16/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5092391 | 0.98 | KIF11 (0.80) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Bromide SCHEMBL5085165 | 0.98 | KIF11 (0.80) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5086796 | 0.98 | KIF11 (0.80) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5085141 | 0.98 | KIF11 (0.80) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Iodide SCHEMBL5092420 | 0.98 | KIF11 (0.80) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Bromide SCHEMBL5087839 | 0.98 | KIF11 (0.80) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2679441 | 0.91 | KIF11 (1.00) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Bromide SCHEMBL14976365 | 0.89 | KIF11 (0.95) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| Water SCHEMBL11129297 | 0.89 | KIF11 (0.95) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29060869 | 0.85 | KIF11 (0.88) | KIF11KCNH2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716604-B1 | THIOL-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2005-03-16 | — | — | EP | disclosed |
| US-6265558-B1 | COMPOUND OF LINKED NUCLEOSIDES HAVING THIOL GROUP ATTATCHED AT 5-PYRIMIDINE OR 2-, 6-, OR 8-PURINE POSITIONS; ATTACHMENT REPORTER MOLECULES, REPORTER ENZYMES, STEROIDS, LIPOPHILIC MOLECULES, PEPTIDES, PROTEINS AND OTHER GROUPS | ISIS PHARMACEUTICALS, INC. | 2001-07-24 | — | — | US | disclosed |
| US-6114513-A | MEDICAL DIAGNOSIS; TRANSFER ACROSS CELL MEMBRANES | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| US-5852182-A | Thiol-derivatized oligonucleosides | ISIS PHARMACEUTICALS INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5578718-A | Thiol-derivatized nucleosides | ISIS PHARMACEUTICALS, INC. (US) | 1996-11-26 | — | — | US | disclosed |