Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474890 | 0.84 | GAA (0.96) | GAASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL5349459 | 0.80 | GAA (0.71) | GAAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6121111 | 0.80 | GAA (0.71) | GAASMN1; SMN2ALDH1A1POLBRECQL | |
| Hydrochloric Acid SCHEMBL17559456 | 0.79 | GAA (0.69) | GAAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL29268525 | 0.79 | GAA (0.69) | GAASMN1; SMN2ALDH1A1POLBRECQL | |
| SCHEMBL947052 | 0.77 | HPGD (0.68) | SMN1; SMN2ALDH1A1NPC1RAB9ANFKB1 | |
| SCHEMBL20236266 | 0.76 | CYP2C9 (0.65) | GAAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL885731 | 0.75 | DRD4 (0.59) | GAASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL11269709 | 0.75 | MAPT (0.56) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL2195779 | 0.74 | MEN1 (0.69) | GAASMN1; SMN2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560815-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | Aventis Pharma Deutschland GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004041788-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |