Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262402 | 0.84 | KMT2A (0.54) | MAPTALDH1A1HPGDKMT2APOLB | |
| SCHEMBL20460493 | 0.81 | HPGD (0.64) | ALDH1A1HPGDHSD17B10RAB9ANAPRT | |
| SCHEMBL11269706 | 0.75 | MAPT (0.46) | MAPTALDH1A1HPGDTDP1POLB | |
| SCHEMBL103123 | 0.71 | RAB9A (0.61) | MAPTALDH1A1KMT2ATDP1POLB | |
| SCHEMBL1725139 | 0.69 | NAPRT (0.62) | KMT2ATDP1POLBRAB9ANPC1 | |
| SCHEMBL2981251 | 0.68 | NAPRT (0.60) | MAPTALDH1A1KMT2ATDP1POLB | |
| SCHEMBL31295356 | 0.68 | NAPRT (0.60) | MAPTALDH1A1KMT2ATDP1POLB | |
| SCHEMBL931481 | 0.68 | NAPRT (0.60) | MAPTALDH1A1KMT2ATDP1POLB | |
| SCHEMBL13360508 | 0.68 | NAPRT (0.60) | MAPTALDH1A1KMT2ATDP1POLB | |
| SCHEMBL11555293 | 0.68 | KCNQ3 (0.64) | MAPTALDH1A1KMT2ANPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004187-B1 | HETEROCYCLYLCARBONYL DERIVATIVES OF UREA AND THEIR USE AS AGENTS FOR DISSOLUTION OF GALLSTONES | PFIZER INC. (US) | 1982-03-17 | — | — | EP | claimed |
| EP-0004187-A1 | Heterocyclylcarbonyl derivatives of urea and their use as agents for dissolution of gallstones | PFIZER INC. (US) | 1979-09-19 | — | — | EP | claimed |
| EP-0004187-B1 | HETEROCYCLYLCARBONYL DERIVATIVES OF UREA AND THEIR USE AS AGENTS FOR DISSOLUTION OF GALLSTONES | PFIZER INC. (US) | 1982-03-17 | — | — | EP | disclosed |