Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 17/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 1/20 | 0.59 |
| ▸ | PRKCH | P24723 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 1/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829004 | 0.90 | WEE1 (0.78) | WEE1CHEK1PRKCQDAPK3JAK2 | |
| SCHEMBL5829115 | 0.88 | WEE1 (0.71) | WEE1CHEK1PRKCQMEN1PRKD3 | |
| SCHEMBL5829088 | 0.88 | WEE1 (0.78) | WEE1CHEK1PRKCQDAPK3JAK2 | |
| SCHEMBL6228285 | 0.87 | WEE1 (0.72) | WEE1CHEK1 | |
| SCHEMBL5828572 | 0.85 | WEE1 (0.72) | WEE1CHEK1 | |
| SCHEMBL5829042 | 0.84 | WEE1 (1.00) | WEE1CHEK1PRKCQMEN1PRKD3 | |
| SCHEMBL5827790 | 0.82 | WEE1 (1.00) | WEE1CHEK1PRKCQMEN1PRKD3 | |
| SCHEMBL5828678 | 0.81 | WEE1 (1.00) | WEE1CHEK1PRKCQMEN1PRKD3 | |
| SCHEMBL5829344 | 0.78 | WEE1 (0.81) | WEE1CHEK1PRKCQDAPK3JAK2 | |
| SCHEMBL5828477 | 0.77 | WEE1 (0.69) | WEE1CHEK1PRKCQDAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |