Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6029902 | 0.86 | HSD17B10 (0.40) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6031351 | 0.86 | HSD17B10 (0.42) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6029620 | 0.86 | ALOX15 (0.48) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6030542 | 0.85 | HSD17B10 (0.51) | HSD17B10ALDH1A1L3MBTL1TSHRHPGD | |
| SCHEMBL6030817 | 0.80 | HSD17B10 (0.55) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6030807 | 0.80 | HSD17B10 (0.55) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6031371 | 0.80 | HSD17B10 (0.55) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6031071 | 0.80 | HSD17B10 (0.55) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6029945 | 0.80 | HSD17B10 (0.55) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL6031127 | 0.80 | HSD17B10 (0.55) | HSD17B10ALDH1A1L3MBTL1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467978-A4 | PANCREATIC LIPASE INHIBITOR COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1467978-A1 | PANCREATIC LIPASE INHIBITOR COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003053944-A1 | PANCREATIC LIPASE INHIBITOR COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |