Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | PTPRB | P23467 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838480 | 0.93 | PTPN1 (0.62) | PTPN1PTPN2PTPRBNPC1RAB9A | |
| SCHEMBL6208795 | 0.78 | PTPN1 (0.59) | PTPN1PTPN2PTPRBCYP2C9ALDH1A1 | |
| SCHEMBL5837471 | 0.77 | PTPN1 (0.46) | PTPN1PTPN2PTPRBNPC1RAB9A | |
| SCHEMBL5838411 | 0.76 | PTPN1 (0.57) | PTPN1PTPN2PTPRBRAB9ASMN1; SMN2 | |
| SCHEMBL5838673 | 0.76 | PTPN1 (0.53) | PTPN1PTPN2PTPRB | |
| SCHEMBL6314421 | 0.73 | PTPN1 (0.54) | PTPN1PTPN2PTPRBNPC1RAB9A | |
| SCHEMBL5838028 | 0.72 | PTPN1 (0.63) | PTPN1PTPN2PTPRB | |
| SCHEMBL5837045 | 0.72 | PTPN1 (0.52) | PTPN1PTPN2PTPRB | |
| SCHEMBL5843149 | 0.71 | PTPN1 (0.55) | PTPN1PTPN2PTPRBCA2SMN1; SMN2 | |
| SCHEMBL7861190 | 0.71 | CYP1A2 (0.42) | PTPN1PTPN2PTPRBLMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |