Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6229035 | 1.00 | MAPT (0.44) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6231481 | 0.93 | MAPT (0.48) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6233243 | 0.93 | MAPT (0.48) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6228192 | 0.92 | GAA (0.47) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6228199 | 0.92 | GAA (0.47) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5889926 | 0.90 | MAPT (0.43) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6230951 | 0.90 | MAPT (0.45) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6230955 | 0.90 | MAPT (0.45) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6231466 | 0.90 | MAPT (0.46) | MAPTALDH1A1POLBGRK2LMNA | |
| SCHEMBL6231469 | 0.90 | MAPT (0.46) | MAPTALDH1A1POLBGRK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444197-B1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-03-30 | — | — | EP | claimed |
| EP-1444197-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | Syngenta Participations AG (CH) | 2004-08-11 | — | — | EP | claimed |
| EP-1282595-B1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2004-07-14 | — | — | EP | claimed |
| WO-2003041728-A9 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2004-04-22 | — | — | WO | claimed |
| US-6683211-B1 | FUNGICIDES FOR CROPS | SYNGENTA CROP PROTECTION, INC. | 2004-01-27 | — | — | US | claimed |
| WO-2003041728-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-05-22 | — | — | WO | claimed |
| EP-1282595-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | Syngenta Participations AG (CH) | 2003-02-12 | — | — | EP | claimed |
| WO-2001087822-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-11-22 | — | — | WO | claimed |
| EP-1444197-B1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-03-30 | — | — | EP | disclosed |
| US-20050026785-A1 | Novel phenyl-propargylether derivatives | SYNGENTA CROP PROTECTION, INC. | 2005-02-03 | — | — | US | disclosed |
| EP-1444197-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | Syngenta Participations AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| EP-1282595-B1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003041728-A9 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2004-04-22 | — | — | WO | disclosed |
| US-6683211-B1 | FUNGICIDES FOR CROPS | SYNGENTA CROP PROTECTION, INC. | 2004-01-27 | — | — | US | disclosed |
| WO-2003041728-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-05-22 | — | — | WO | disclosed |
| EP-1282595-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | Syngenta Participations AG (CH) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001087822-A1 | NOVEL PHENYL-PROPARGYLETHER DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026785-A1 | Novel phenyl-propargylether derivatives | OR10J3, PRXL2A, OSR1 | MAPT 4672/4885ALDH1A1 1556/4885POLB 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.