PRXL2A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to PRXL2A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
A Study Evaluating Megestrol Acetate Modulation in Hormone Receptor Positive Advanced Breast Cancer	PHASE2	UNKNOWN
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo/in Vitro Studies	nan	NOT_YET_RECRUITING
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm	nan	COMPLETED
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
Evolution of Visual Impairment During Pseudoxanthoma Elasticum	nan	COMPLETED
X-Chromosome Inactivation Status and Premature Ovarian Failure	nan	COMPLETED
Vitreous Proteomics of Patients Suffering From Pseudoexfoliation Syndrome	nan	ACTIVE_NOT_RECRUITING
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Study of the Disease Process of Lymphangioleiomyomatosis	nan	RECRUITING
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders	nan	COMPLETED
Genetic Study of Age-Related Macular Degeneration	nan	COMPLETED
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Prospective Genetic Study in Patients With Ovarian Insufficiency	nan	UNKNOWN
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
The Etiology and Progression of Brain Tumors	nan	COMPLETED
Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRXL2A binder may also engage these)

Protein	Name	Similarity
Q6AXX6	—	1.000	Q6AXX6 →
Q3ZBK2	—	1.000	Q3ZBK2 →
Q9CYH2	—	1.000	Q9CYH2 →
A0JPD7	—	1.000	A0JPD7 →
Q5ZI34	—	1.000	Q5ZI34 →
Q641F0	—	0.999	Q641F0 →
Q6PBP3	—	0.994	Q6PBP3 →
Q8AV19	—	0.988	Q8AV19 →
Q9ZUU2	—	0.983	Q9ZUU2 →
Q6DW73	—	0.982	Q6DW73 →
Q9ZVN2	—	0.981	Q9ZVN2 →
Q9LW26	—	0.980	Q9LW26 →
Q6DW75	—	0.979	Q6DW75 →
Q2QEI3	—	0.979	Q2QEI3 →
Q9JM53	—	0.977	Q9JM53 →
P16638	—	0.977	P16638 →
Q6FWV2	—	0.976	Q6FWV2 →
P06623	—	0.976	P06623 →
O42411	—	0.976	O42411 →
A0A1D6NER6	—	0.976	A0A1D6NER6 →
Q5YLB4	—	0.976	Q5YLB4 →
P36101	—	0.976	P36101 →
Q804E1	—	0.976	Q804E1 →
Q5I3B2	—	0.975	Q5I3B2 →
Q8H1Z0	—	0.975	Q8H1Z0 →
Q6QN13	—	0.975	Q6QN13 →
Q53EU6	—	0.975	Q53EU6 →
AIFM1	Apoptosis-inducing factor 1, mitochondrial	0.975	landscape →
Q6NV24	—	0.974	Q6NV24 →
B0XPV4	—	0.974	B0XPV4 →