Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29733231 | 1.00 | MAPT (0.47) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL29733134 | 0.84 | MAPT (0.48) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL27203249 | 0.83 | TDP1 (0.46) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL15450803 | 0.82 | KMT2A (0.50) | MAPTTDP1MEN1KMT2ARAB9A | |
| SCHEMBL4926496 | 0.82 | MAPT (0.56) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL7029404 | 0.81 | DDAH1 (0.58) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL23793903 | 0.81 | MAPT (0.55) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL10264201 | 0.79 | PIM1 (0.47) | MAPTKDM4ETDP1RAB9ASMN1; SMN2 | |
| SCHEMBL8807127 | 0.79 | MAPT (0.55) | MAPTKDM4EPKMTDP1MEN1 | |
| SCHEMBL10955133 | 0.78 | BCHE (0.40) | MAPTKDM4ETDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853679-A | Benzimidazole ENL protein inhibitor and preparation method and application thereof | 清药同创(北京)药物研发中心有限公司 | 2022-08-05 | — | — | CN | disclosed |
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |