Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231663 | 0.80 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL31733652 | 0.71 | PARP15 (0.45) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| Hydrochloric Acid SCHEMBL31733434 | 0.70 | TDP1 (0.44) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| Hydrochloric Acid SCHEMBL31733389 | 0.70 | TDP1 (0.44) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| SCHEMBL17204380 | 0.69 | PARP15 (0.55) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| SCHEMBL17204624 | 0.68 | PARP10 (0.54) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| SCHEMBL981699 | 0.67 | TDP1 (0.46) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| SCHEMBL17131595 | 0.67 | TDP1 (0.46) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| SCHEMBL31733722 | 0.67 | CACNA1B (0.44) | PDE4BPDE4APDE4CPDE4DPARP15 | |
| SCHEMBL21494488 | 0.67 | MTNR1A (0.46) | ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |