Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.38 |
| ▸ | FADS1 | O60427 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238034 | 0.89 | GAA (0.45) | GAAMAPTNPY5RPOLA1SLC2A1 | |
| SCHEMBL6235371 | 0.86 | MAPT (0.42) | GAAMAPTNPY5RPOLA1SLC2A1 | |
| SCHEMBL6233025 | 0.86 | MAPT (0.42) | GAAMAPTNPY5RPOLA1SLC2A1 | |
| SCHEMBL6235222 | 0.86 | GAA (0.47) | GAAMAPTNPY5RPOLA1SLC2A1 | |
| SCHEMBL6231640 | 0.86 | SLC2A1 (0.48) | GAAMAPTNPY5RSLC2A1MEN1 | |
| SCHEMBL6235120 | 0.86 | NPY5R (0.47) | MAPTNPY5RPOLA1SLC2A1MEN1 | |
| SCHEMBL6232210 | 0.84 | MAPT (0.45) | GAAMAPTMEN1KMT2APOLB | |
| SCHEMBL6086853 | 0.84 | GAA (0.50) | GAAMAPTNPY5RPOLA1SLC2A1 | |
| SCHEMBL6238037 | 0.82 | NPY5R (0.60) | MAPTNPY5RPOLA1SLC2A1MEN1 | |
| SCHEMBL6089980 | 0.81 | GAA (0.54) | GAAMAPTNPY5RPOLA1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |