Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.41 |
| ▸ | POLA1 | P09884 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238034 | 0.90 | GAA (0.45) | MAPTGAAMAPK14POLA1KMT2A | |
| SCHEMBL6235371 | 0.87 | MAPT (0.42) | MAPTGAAPOLA1KMT2AMEN1 | |
| SCHEMBL6233510 | 0.87 | MAPK14 (0.41) | MAPTGAAMAPK14MAPK13MAPK12 | |
| SCHEMBL6235222 | 0.87 | GAA (0.47) | MAPTGAAPOLA1KMT2AMEN1 | |
| SCHEMBL6231640 | 0.87 | SLC2A1 (0.48) | MAPTGAAMAPK14MAPK13MAPK12 | |
| SCHEMBL6231003 | 0.86 | GAA (0.48) | MAPTGAAPOLA1KMT2AMEN1 | |
| SCHEMBL6232210 | 0.84 | MAPT (0.45) | MAPTGAAMAPK14MAPK13MAPK12 | |
| SCHEMBL6233775 | 0.83 | SLC2A1 (0.50) | MAPTGAAMAPK14MAPK13MAPK12 | |
| SCHEMBL6235684 | 0.80 | TP53 (0.43) | MAPTGAAMAPK14MAPK13MAPK12 | |
| SCHEMBL6086853 | 0.80 | GAA (0.50) | MAPTGAAPOLA1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |