Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231072 | 0.84 | ESR2 (0.53) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6539871 | 0.84 | ESR2 (0.53) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6208355 | 0.80 | ESR2 (0.49) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6233898 | 0.80 | ESR2 (0.49) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6538831 | 0.79 | ESR2 (0.47) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6539500 | 0.79 | ESR2 (0.47) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6230071 | 0.79 | ESR2 (0.47) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6231751 | 0.78 | IKBKB (0.47) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6208111 | 0.78 | ESR2 (0.47) | ESR2NOX1ESR1MAPTTP53 | |
| SCHEMBL6539632 | 0.77 | ESR2 (0.45) | ESR2NOX1ESR1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583749-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | Astellas Pharma Inc. (JP) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004065374-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | ASTELLAS PHARMA INC. (JP) | 2004-08-05 | — | — | WO | disclosed |