Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4216777 | 1.00 | GAA (0.49) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL4216778 | 1.00 | GAA (0.49) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL31126626 | 0.83 | GAA (0.47) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5097078 | 0.81 | GAA (0.46) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5097083 | 0.81 | GAA (0.46) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5591074 | 0.78 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9MAPTRECQL | |
| SCHEMBL3289588 | 0.78 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9MAPTRECQL | |
| SCHEMBL9183556 | 0.74 | GAA (0.45) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL22833125 | 0.73 | GAA (0.51) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL13545621 | 0.72 | GAA (0.69) | GAAALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005295-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |