SCHEMBL6231365

SCHEMBL6231365

Cc1cc(O)nc2c(N)cccc12

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.69
TDP1 Q9NUW8 3/20 0.69
PARP1 P09874 1/20 0.46
ELANE P08246 1/20 0.46
LMNA P02545 3/20 0.45
GAA P10253 3/20 0.45
TSHR P16473 3/20 0.45
HTT P42858 3/20 0.45
MITF O75030 2/20 0.45
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.45
TP53 P04637 1/20 0.45
AGTR1 P30556 1/20 0.45
PKM P14618 1/20 0.42
BACE1 P56817 1/20 0.41
NR4A2 P43354 1/20 0.40
CCR1 P32246 1/20 0.40
CCR8 P51685 1/20 0.40
ALDH1A1 P00352 4/20 0.38
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29631413 0.83 KDM4E (0.51) KDM4ETDP1PARP1ELANELMNA
SCHEMBL935117 0.83 KDM4E (0.51) KDM4ETDP1PARP1ELANELMNA
SCHEMBL11585401 0.81 KDM4E (1.00) KDM4ETDP1PARP1ELANELMNA
SCHEMBL9807469 0.81 TDP1 (0.49) KDM4ETDP1PARP1ELANETSHR
SCHEMBL18553852 0.79 KDM4E (0.42) KDM4ETDP1PARP1LMNAGAA
SCHEMBL30612099 0.79 MAPT (0.47) KDM4ETDP1LMNAGAATSHR
SCHEMBL26103062 0.79 MAPT (0.47) KDM4ETDP1LMNAGAATSHR
SCHEMBL11692297 0.75 KDM4E (0.69) KDM4ETDP1PARP1ELANELMNA
SCHEMBL23622861 0.75 KDM4E (0.63) KDM4ETDP1PARP1ELANELMNA
SCHEMBL10763470 0.75 CRHR1 (0.48) KDM4ETDP1CCR1CCR8ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1517962-A1 METHOD FOR PRODUCING DISAZO PIGMENTS Clariant GmbH (DE) 2005-03-30 EP disclosed
WO-2004000947-A1 METHOD FOR PRODUCING DISAZO PIGMENTS CLARIANT GMBH (DE) 2003-12-31 WO disclosed
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
EP-0518909-B1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AG (DE) 1994-05-25 EP disclosed
EP-0585873-A1 Method of preparing disazo pigments HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-09 EP disclosed
EP-0518909-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE. HOECHST AG (DE) 1992-12-23 EP disclosed
EP-0316649-B1 WATER INSOLUBLE AZO COLOURING AGENTS, THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-22 EP disclosed
WO-1991013941-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-09-19 WO disclosed