Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.45 |
| ▸ | ESR1 | P03372 | 5/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589434 | 1.00 | NR3C1 (0.45) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL4587863 | 0.90 | NR3C1 (0.42) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL4589186 | 0.88 | NR3C1 (0.41) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL6232518 | 0.85 | NR3C1 (0.41) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL1829950 | 0.85 | NR3C1 (0.41) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL6232522 | 0.85 | NR3C1 (0.41) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL5677972 | 0.83 | ESR1 (0.47) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL6260433 | 0.83 | ESR1 (0.47) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL4587935 | 0.76 | NR3C1 (0.41) | NR3C1ESR1ESR2PGRAR | |
| SCHEMBL4587939 | 0.76 | NR3C1 (0.41) | NR3C1ESR1ESR2PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517914-A2 | 9-ALPHA-SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGEN | Schering Aktiengesellschaft (DE) | 2005-03-30 | — | — | EP | disclosed |
| WO-2003104253-A2 | 9-ALPHA-SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGEN | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-12-18 | — | — | WO | disclosed |