Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.77 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | ABL2 | P42684 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901174 | 0.96 | SRC (0.83) | SRCMAP2K1MAPK13MAP3K8MAPK12 | |
| SCHEMBL4900882 | 0.89 | SRC (0.72) | SRCMAP2K1MAPK13MAP3K8MAPK12 | |
| SCHEMBL4892616 | 0.87 | SRC (1.00) | SRCMAP2K1RAF1PRKCQPRKCD | |
| Methylpiperazine SCHEMBL6315124 | 0.83 | SRC (0.91) | SRCMAP2K1RAF1PRKCQPRKCD | |
| SCHEMBL3229498 | 0.78 | MAP2K1 (0.67) | SRCMAP2K1MAPK13MAP3K8MAPK12 | |
| SCHEMBL3219501 | 0.78 | MAP2K1 (0.69) | SRCMAP2K1MAPK13MAP3K8MAPK12 | |
| SCHEMBL4901161 | 0.76 | SRC (0.65) | SRCMAP2K1MAPK13MAP3K8MAPK12 | |
| SCHEMBL3223956 | 0.76 | MAP2K1 (0.71) | SRCMAP2K1MAPK13MAP3K8MAPK12 | |
| SCHEMBL4900669 | 0.76 | SRC (0.86) | SRCMAP2K1RAF1ABL1ABL2 | |
| SCHEMBL3229392 | 0.75 | MAP2K1 (0.69) | SRCMAP2K1MAPK13MAP3K8MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565474-A2 | THIENO[3,2-B]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048386-A9 | THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2005-07-14 | — | — | WO | disclosed |
| WO-2004048386-A2 | THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2004-06-10 | — | — | WO | disclosed |