Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.91 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | ABL2 | P42684 | 2/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892616 | 0.96 | SRC (1.00) | SRCABL1ABL2PRKCQPRKCD | |
| SCHEMBL4901174 | 0.87 | SRC (0.83) | SRCABL1ABL2PRKCQPRKCD | |
| Methylpiperazine SCHEMBL6230502 | 0.85 | SRC (0.70) | SRCABL1ABL2EGFRRAF1 | |
| SCHEMBL6231708 | 0.83 | SRC (0.77) | SRCABL1ABL2PRKCQPRKCD | |
| Methylpiperazine SCHEMBL6232650 | 0.81 | SRC (0.92) | SRCABL1ABL2EGFRRAF1 | |
| SCHEMBL4900882 | 0.81 | SRC (0.72) | SRCRAF1MAP2K1 | |
| SCHEMBL4896294 | 0.80 | SRC (0.75) | SRCABL1ABL2EGFRRAF1 | |
| SCHEMBL13480823 | 0.80 | SRC (0.71) | SRCABL1ABL2PRKCQPRKCD | |
| SCHEMBL4897988 | 0.79 | SRC (0.81) | SRCABL1ABL2EGFRRAF1 | |
| SCHEMBL4904389 | 0.79 | SRC (0.73) | SRCABL1ABL2EGFRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565474-A2 | THIENO[3,2-B]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048386-A2 | THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2004-06-10 | — | — | WO | disclosed |