Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E known ✓ | P49674 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17179997 | 1.00 | CNR2 (0.43) | CNR2CSNK1EALDH1A1LMNAGAA | |
| SCHEMBL17180009 | 0.86 | CSNK1E (0.49) | CNR2CSNK1EALDH1A1LMNA | |
| SCHEMBL10415255 | 0.86 | CNR2 (0.41) | CNR2CSNK1EALDH1A1LMNAMCHR1 | |
| Toluene SCHEMBL28069293 | 0.85 | CSNK1E (0.49) | CNR2CSNK1E | |
| SCHEMBL10531180 | 0.83 | CNR2 (0.41) | CNR2CSNK1EGAAMCHR1CYP2D6 | |
| Bicarbonate SCHEMBL8164473 | 0.82 | CSNK1E (0.52) | CNR2CSNK1E | |
| Bicarbonate SCHEMBL8168589 | 0.82 | CSNK1E (0.52) | CNR2CSNK1E | |
| SCHEMBL10773798 | 0.82 | CSNK1E (0.54) | CNR2CSNK1E | |
| SCHEMBL8079460 | 0.82 | CSNK1E (0.54) | CNR2CSNK1E | |
| SCHEMBL22442308 | 0.82 | CSNK1E (0.54) | CNR2CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658818-B1 | Toner compositions with compatibilizer | XEROX CORP (US) | 2000-02-02 | — | — | EP | claimed |
| US-5994017-A | MIXTURE OF RESIN, COLORANT, WAX AND AN ACRYLATE POLYMER COMPATIBILIZER | XEROX CORPORATION (US) | 1999-11-30 | — | — | US | claimed |
| US-5955235-A | Toner compositions with compatibilizers | XEROX CORPORATION (US) | 1999-09-21 | — | — | US | claimed |
| US-5843612-A | Toner and developer compositions with compatibilizers | XEROX CORPORATION (US) | 1998-12-01 | — | — | US | claimed |
| US-5688625-A | Toner compositions with dispersed wax | XEROX CORPORATION (US) | 1997-11-18 | — | — | US | claimed |
| EP-0276147-B1 | Toner and developer compositions with long chain alcohol waxes | XEROX CORP (US) | 1996-12-27 | — | — | EP | claimed |
| US-5516612-A | PROVIDING DEVELOPER PARTICLES OF RESINOUS TONER, CHARGE,SURFACE AND CONTROL RETENTION ADDITIVES AND CARRIER | XEROX CORPORATION (US) | 1996-05-14 | — | — | US | claimed |
| US-5486445-A | Toner and developer compositions with diblock compatibilizers | XEROX CORPORATION (US) | 1996-01-23 | — | — | US | claimed |
| EP-0658818-A1 | Toner compositions with compatibilizer | XEROX CORPORATION (US) | 1995-06-21 | — | — | EP | claimed |
| US-5368970-A | Toner compositions with compatibilizer | XEROX CORPORATION (US) | 1994-11-29 | — | — | US | claimed |
| US-4960665-A | Toner and developer compositions containing additives with certain morphologies | XEROX CORPORATION (US) | 1990-10-02 | — | — | US | claimed |
| US-4912005-A | Toner and developer compositions with conductive carrier components | XEROX CORPORATION (US) | 1990-03-27 | — | — | US | claimed |
| US-4891293-A | Toner and developer compositions with thermotropic liquid crystalline polymers | XEROX CORPORATION (US) | 1990-01-02 | — | — | US | claimed |
| US-4883736-A | Electrophotographic toner and developer compositions with polymeric alcohol waxes | XEROX CORPORATION (US) | 1989-11-28 | — | — | US | claimed |
| US-4837105-A | Imaging process with prevention of toner spots | XEROX CORPORATION (US) | 1989-06-06 | — | — | US | claimed |
| US-4820604-A | Toner and developer compositions with sulfur cotaining organopolysiloxane waxes | XEROX CORPORATION (US) | 1989-04-11 | — | — | US | claimed |
| EP-0276147-A2 | Toner and developer compositions with long chain alcohol waxes | XEROX CORPORATION (US) | 1988-07-27 | — | — | EP | claimed |
| EP-0274858-A1 | Toner compositions with inner salt charge enhancing additives | XEROX CORPORATION (US) | 1988-07-20 | — | — | EP | claimed |
| US-4752550-A | Toner compositions with inner salt charge enhancing additives | XEROX CORPORATION (US) | 1988-06-21 | — | — | US | claimed |
| US-4681829-A | Single component red developer compositions | XEROX CORPORATION (US) | 1987-07-21 | — | — | US | claimed |