Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.49 |
| ▸ | LIPE | Q05469 | 16/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12702535 | 0.82 | LIPE (0.46) | EBPLIPETRPV1 | |
| SCHEMBL12702532 | 0.82 | LIPE (0.46) | EBPLIPETRPV1 | |
| SCHEMBL10061 | 0.82 | LIPE (0.46) | EBPLIPETRPV1 | |
| SCHEMBL10062 | 0.82 | LIPE (0.46) | EBPLIPETRPV1 | |
| SCHEMBL1589334 | 0.82 | LIPE (0.46) | EBPLIPETRPV1 | |
| SCHEMBL12702580 | 0.80 | EBP (0.44) | EBPLIPETRPV1 | |
| SCHEMBL1589896 | 0.80 | EBP (0.44) | EBPLIPETRPV1 | |
| SCHEMBL1589897 | 0.80 | EBP (0.44) | EBPLIPETRPV1 | |
| SCHEMBL5644 | 0.80 | EBP (0.46) | EBPLIPETRPV1HRH3 | |
| SCHEMBL9978 | 0.79 | TRPV1 (0.46) | EBPLIPETRPV1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488493-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045292-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-21 | — | — | WO | disclosed |