Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442509 | 0.86 | MAPT (0.48) | GPR35TDP1MAPTMEN1KMT2A | |
| SCHEMBL3022006 | 0.84 | ALDH1A1 (0.55) | GPR35TDP1MAPTMEN1KMT2A | |
| SCHEMBL30235266 | 0.83 | HTT (0.58) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL5407163 | 0.83 | HTT (0.58) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL18087973 | 0.83 | HTT (0.58) | TDP1MAPTMEN1KMT2AHTT | |
| SCHEMBL6275912 | 0.82 | ALDH1A1 (0.52) | GPR35TDP1MAPTMEN1KMT2A | |
| SCHEMBL443353 | 0.82 | TDP1 (0.64) | GPR35TDP1MAPTMEN1KMT2A | |
| SCHEMBL31375357 | 0.82 | TDP1 (0.64) | GPR35TDP1MAPTMEN1KMT2A | |
| SCHEMBL27714825 | 0.81 | CYP19A1 (0.56) | GPR35MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2766450 | 0.81 | MAPT (0.63) | TDP1MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422737-B | Imidazolone androgen receptor antagonist, preparation method and application thereof | 上海时莱生物技术有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-109422737-A | Imidazolone androgen receptor antagonists, preparation method and use | 上海时莱生物技术有限公司 | 2019-03-05 | — | — | CN | disclosed |
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |