Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498074 | 0.87 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL6229490 | 0.85 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6233638 | 0.84 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL6228923 | 0.84 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6229565 | 0.84 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL6229342 | 0.84 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL6228237 | 0.84 | PDE4B (0.48) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6232762 | 0.82 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL6226932 | 0.82 | PDE4A (0.42) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL6232676 | 0.79 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |