Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6228923 | 0.93 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6232762 | 0.89 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6232341 | 0.85 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL498074 | 0.83 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6228447 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6228237 | 0.81 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6229565 | 0.81 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6229342 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6227157 | 0.80 | SIGMAR1 (0.48) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL6233638 | 0.79 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |